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MDMB-CHMINACA is an indazole-based synthetic cannabinoid that acts as a potent agonist of the CB₁ receptor, and has been sold online as a designer drug. It was invented by Pfizer in 2008, and is one of the most potent cannabinoid agonists known, with a binding affinity of 0.0944 nM at CB₁, and an EC₅₀ of 0.330 nM
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MMB-CHMINACA is an indazole-based synthetic cannabinoid also known as MDMB-CHMCA, AMB-CHMINACA and MA-CHMINACA. Its molecular formula is N-[[1-(cyclohexylmethyl)-1H-indazol-3-yl]carbonyl]-L-valine, methyl ester (C21H29N3O3) . It acts a potent agonist upon CB1 cannabinoid receptors. It’s an analog of AB-CHMINACA, whereby the hydroxyl moiety is replaced with a methyl ester group .
MMB-CHMINACA has been mentioned in scientific journals only in the context of reports on its effects on hospitalized patients. While it hasn’t been looked at in a controlled lab study, scientists have noted that its molecular structure is significantly more complex than both THC and synthetic cannabinoids of the “first generation” such as JHW018 .
Also, one 2017 study published in “Substance Use and Misuse” compiled anecdotal evidence from MMB-CHMINACA users posted online, to get a general sense for its effect. The study found that acccording to anecdotal evidence, the most common positive effect of MMB-CHMINACA is reported to be euphoria. The most common negative effects reported anecdotally are heart palpitations, vomiting, loss of consciousness, chest pain and anxiety. There are also some reports of visual hallucinations .
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